Mackert A, Flechtner K M, Woyth C, Frick K
Department of Psychiatry Free University of Berlin, F.R.G.
Schizophr Res. 1991 Jan-Feb;4(1):41-7. doi: 10.1016/0920-9964(91)90008-f.
During a standardized visuomotor task, eye blinking, a possible parameter of central dopaminergic activity, was studied in 18 previously medicated and eight drug-naive schizophrenic in-patients in the acute state and during remission. Whereas schizophrenics executed the visuomotor task with the same precision as age- and sex-matched normal control subjects did, the mean blink rate was increased in both schizophrenic groups. During neuroleptic treatment, the mean blink rate was reduced only in the group of drug-naive patients, but not in the previously neuroleptic treated schizophrenics. This varying blinking activity is discussed with respect to the development of neuroleptic tolerance and influence of psychopathology.
在一项标准化视觉运动任务中，对18名曾接受过药物治疗的急性发作期和缓解期精神分裂症住院患者以及8名未使用过药物的急性发作期精神分裂症住院患者进行了研究，眨眼是中枢多巴胺能活动的一个可能参数。虽然精神分裂症患者执行视觉运动任务的精度与年龄和性别匹配的正常对照受试者相同，但两个精神分裂症组的平均眨眼率均有所增加。在抗精神病药物治疗期间，只有未使用过药物的患者组平均眨眼率降低，而之前接受过抗精神病药物治疗的精神分裂症患者组则没有降低。针对抗精神病药物耐受性的发展和精神病理学的影响，对这种不同的眨眼活动进行了讨论。
