Mutayoba B M, Meyer H H, Osaso J, Gombe S
Reproductive Biology Unit, University of Nairobi P.O.Box 30197, Nairobi, Kenya.
Theriogenology. 1989 Oct;32(4):545-55. doi: 10.1016/0093-691x(89)90276-8.
Plasma progesterone and 13,14-dihydro-15-keto Prostaglandin F(2alpha) (PGFM) were measured in normal (uninfected) and Trypanosoma congolense -infected adult goats for a period of 121 d, from May to August, during the breeding season in Kenya. Chronic trypanosomiasis rapidly increased the baseline plasma PGFM levels and the occurrence of irregular PGFM peaks in several infected goats. Progesterone luteal levels declined rapidly from the second and subsequent cycles post patency. Estrous cycles also became irregular but predominately shorter (8 to 19 d) before cessation from the second to fourth cycle following infection. The PGFM levels were still high during the acyclic period in all goats when progesterone levels were very low (1.4 to 2.4 nmol/l). The reciprocal increase in peripheral PGFM and decline in progesterone in these goats would suggest, in part, a trypanosome-induced PGF(2alpha) mediated luteolysis, and the possible involvement of prostaglandins in trypanosome-induced infertility in female goats.
在肯尼亚的繁殖季节，即5月至8月期间，对正常（未感染）和感染刚果锥虫的成年山羊进行了为期121天的血浆孕酮和13,14 - 二氢 - 15 - 酮前列腺素F（2α）（PGFM）测量。慢性锥虫病迅速提高了几只感染山羊的血浆PGFM基线水平，并增加了不规则PGFM峰值的出现频率。从通畅后的第二个及后续周期开始，孕酮黄体水平迅速下降。发情周期也变得不规则，但在感染后的第二个至第四个周期停止前，主要变短（8至19天）。在所有山羊的无周期期间，当孕酮水平非常低（1.4至2.4 nmol/l）时，PGFM水平仍然很高。这些山羊外周PGFM的相互增加和孕酮的下降部分表明，锥虫诱导的PGF（2α）介导了黄体溶解，并且前列腺素可能参与了锥虫诱导的雌性山羊不育。
