Bonnett B N, Etherington W G, Martin S W, Johnson W H
Department of Population Medicine Ontario Veterinary College University of Guelph Guelph, Ontario, Canada N1G 2W1.
Theriogenology. 1990 Apr;33(4):877-90. doi: 10.1016/0093-691x(90)90823-c.
Ninety-two cows that calved between April and August 1984 in a commercial dairy herd were studied. The cows were randomly assigned to receive either cloprostenol (500 mug) or saline placebo on Day 26 postpartum. In addition, each cow was examined per rectum, had three endometrial biopsies taken and milk progesterone level determined. Double-blind techniques were used in administering treatments and in assessing response to treatment. The results of histological and bacteriological assessment of endometrial biopsies and clinical findings at Day 40 were compared between the cows that received prostaglandin at Day 26 and those that did not. Each Day 40 variable which was significantly associated with prostaglandin treatment at Day 26 was regressed against the treatment variable and progesterone level at Day 26 as well as a prostaglandin progesterone interaction term. Prostaglandin-treated cows had less vaginal discharge, smaller diameter uterine horns, less inflammation and fibrosis in the endometrium, and were less likely to have Actinomyces pyogenes isolated from a biopsy at Day 40 than untreated cows. These effects were independent of progesterone level at the time of treatment.
对1984年4月至8月间在一个商业奶牛场产犊的92头奶牛进行了研究。这些奶牛在产后第26天被随机分配接受氯前列醇（500微克）或生理盐水安慰剂。此外，对每头奶牛进行直肠检查，取三次子宫内膜活检样本并测定牛奶孕酮水平。在给药治疗和评估治疗反应时采用了双盲技术。比较了在第26天接受前列腺素治疗的奶牛和未接受治疗的奶牛在第40天子宫内膜活检的组织学和细菌学评估结果以及临床发现。将第40天与第26天前列腺素治疗显著相关的每个变量与治疗变量、第26天的孕酮水平以及前列腺素-孕酮相互作用项进行回归分析。与未治疗的奶牛相比，接受前列腺素治疗的奶牛阴道分泌物更少，子宫角直径更小，子宫内膜炎症和纤维化更少，并且在第40天活检时从活检样本中分离出化脓放线菌的可能性更小。这些影响与治疗时的孕酮水平无关。
