瑞典多发性硬化症患者中与种系T细胞受体β链基因等位基因或单倍型无关联。

No association with germline T cell receptor beta-chain gene alleles or haplotypes in Swedish patients with multiple sclerosis.

作者信息

Hillert J, Leng C, Olerup O

机构信息

Center for BioTechnology, Karolinska Institute, NOVUM, Huddinge, Sweden.

出版信息

J Neuroimmunol. 1991 May;32(2):141-7. doi: 10.1016/0165-5728(91)90006-s.

DOI:10.1016/0165-5728(91)90006-s

PMID:1672869

Abstract

Multiple sclerosis (MS) has been reported to be associated with restriction fragment length polymorphism (RFLP)-defined alleles of the T cell receptor (TcR) alpha- and beta-chain genes. One hundred patients with MS, 23 with primarily chronic progressive MS and 77 with relapsing/remitting MS, as well as 100 controls were investigated with RFLP analysis of the V beta 8, V beta 11 and C beta TcR gene segments. No association was found with allelic patterns or, contrary to a previous report (Beall et al. (1989) J. Neuroimmunol. 21, 59-66), TcR beta-chain gene haplotypes. Subgrouping of patients according to clinical form of disease or MS-associated HLA class II alleles also failed to show associations to TcR beta-chain RFLPs. Thus, our results fail to confirm that TcR beta-chain gene haplotypes confer susceptibility to MS.

摘要

据报道，多发性硬化症（MS）与通过限制性片段长度多态性（RFLP）定义的T细胞受体（TcR）α链和β链基因的等位基因有关。对100例MS患者（其中23例为原发性慢性进行性MS，77例为复发/缓解型MS）以及100名对照进行了Vβ8、Vβ11和Cβ TcR基因片段的RFLP分析。未发现与等位基因模式存在关联，而且与之前的一份报告（Beall等人，（1989年）《神经免疫学杂志》21卷，59 - 66页）相反，也未发现与TcRβ链基因单倍型存在关联。根据疾病的临床形式或与MS相关的HLA II类等位基因对患者进行亚组分析，也未显示出与TcRβ链RFLP存在关联。因此，我们的结果未能证实TcRβ链基因单倍型会使人易患MS。