Raffel O Christopher, White Harvey D
Cardiology Division, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Nat Clin Pract Cardiovasc Med. 2006 Jun;3(6):318-28. doi: 10.1038/ncpcardio0558.
The elderly represent a notable proportion of patients who present with myocardial infarction or acute coronary syndromes. This subgroup of patients also experiences a higher incidence of adverse outcomes than younger age-groups, and, therefore, has more to gain from effective, evidence-based therapies. The efficacy of statins in secondary cardiovascular disease prevention is firmly established. The starting of therapy soon after an acute coronary event has been shown to provide added benefit. Uncertainties about the effectiveness of statins in the elderly, however, have resulted in their underuse in this population. In this review we evaluate the evidence for statin use in this important and increasingly large group of patients.
老年人在出现心肌梗死或急性冠状动脉综合征的患者中占相当比例。与年轻人群相比，这一亚组患者不良结局的发生率也更高，因此，从有效的循证治疗中获益更多。他汀类药物在心血管疾病二级预防中的疗效已得到确证。急性冠状动脉事件后尽早开始治疗已显示可带来额外益处。然而，由于对他汀类药物在老年人中的有效性存在不确定性，导致该人群对其使用不足。在本综述中，我们评估了在这一重要且规模日益庞大的患者群体中使用他汀类药物的证据。
