硝苯地平对杜氏利什曼原虫体内和体外感染的影响：腹膜巨噬细胞和中性粒细胞的化学发光反应
Effect of nifedipine on Leishmania donovani infection in-vivo and in-vitro: chemiluminescence responses of peritoneal macrophages and neutrophils.
作者信息
Ganguly N K, Sodhi S, Kaul N, Kaur S, Malla N, Mahajan R C
机构信息
Department of Parasitology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
出版信息
J Pharm Pharmacol. 1991 Feb;43(2):140-2. doi: 10.1111/j.2042-7158.1991.tb06652.x.
After peritoneal macrophages had been exposed to different concentrations of nifedipine (10-120 ng mL-1) there was a significant increase (P less than 0.001) in the percentage of Leishmania donovani infected macrophages compared with controls. Parasite load was also significantly increased (P less than 0.001) in nifedipine-treated, L. donovani infected, BALB/c mice, compared with untreated, infected mice, post-inoculation. Peak chemiluminescence responses were significantly depressed (P less than 0.001) in nifedipine-treated infected mice compared with untreated mice post-inoculation. It is suggested that availability of intracellular calcium is a factor in the defense mechanism of inflammatory cells in L. donovani infections.
将腹膜巨噬细胞暴露于不同浓度的硝苯地平（10 - 120 ng/mL）后，与对照组相比，感染杜氏利什曼原虫的巨噬细胞百分比显著增加（P < 0.001）。与未处理的感染小鼠相比，接种后，经硝苯地平处理的感染杜氏利什曼原虫的BALB/c小鼠的寄生虫负荷也显著增加（P < 0.001）。与接种后未处理的小鼠相比，经硝苯地平处理的感染小鼠的峰值化学发光反应显著降低（P < 0.001）。提示细胞内钙的可用性是杜氏利什曼原虫感染中炎症细胞防御机制的一个因素。
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