Kaul N, Andrabi K I, Ganguly N K, Wahi P L
Department of Cardiology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Mol Cell Biochem. 1993 Mar 10;120(1):81-5. doi: 10.1007/BF00925987.
Administration of nifedipine to mice over a period of six months caused a significant (p < 0.05) decrease in neutrophilic functions viz superoxide generation, coupled to NADPH oxidase activity as well as NADPH production by HMP shunt. Properties like chemotaxis and phagocytosis showed a similar decrease. From this study, it is seen that nifedipine causes neutrophil functional abrogation which is therefore an apparent concern for the prolonged usage of the drug. However, relevance of the mouse model to clinical situation needs further investigation.
给小鼠服用硝苯地平六个月导致中性粒细胞功能显著（p < 0.05）下降，即超氧化物生成减少，这与NADPH氧化酶活性以及磷酸戊糖途径产生NADPH有关。趋化性和吞噬作用等特性也呈现类似下降。从这项研究可以看出，硝苯地平会导致中性粒细胞功能丧失，因此长期使用该药物显然令人担忧。然而，小鼠模型与临床情况的相关性需要进一步研究。
