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Convenient synthesis of GOLD and MOLD and identification of their oxidation products in vitro and in vivo.

作者信息

Linetsky M D, Shipova E V

机构信息

Mason Eye Institute, University of Missouri-Columbia, Columbia, Missouri, USA.

出版信息

Amino Acids. 2007 Feb;32(2):285-9. doi: 10.1007/s00726-006-0338-6. Epub 2006 May 26.

DOI:10.1007/s00726-006-0338-6
PMID:16729191
Abstract

Two Lys-Lys crosslinks, 1,3-bis-(5-amino-5-carboxypentyl)-1H-imidazolium (GOLD) and 1,3-bis(5-amino-5-carboxypentyl)-4-methyl-1H-imidazolium (MOLD) salts, have been synthesized by the reaction of imidazole or 4(5)-methyl imidazole with 5-(4-bromobutyl)-hydantoin followed by the hydrolysis of 1,3-substituted imidazolium derivatives by 6.0 N HCL at 110 degrees C. Treatment of GOLD and MOLD with hydrogen peroxide in acetic acid leads to MOLD oxidation only. The oxidation product of MOLD was detected in cataractous lens proteins.

摘要

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