Cannizzaro Matteo Angelo, Costanzo Mario, Fiorenza Giuseppe, Cavallaro Annunziata, Galasso Maria Grazia, Arcerito Maria Concetta, Marziani Alessia, Cannizzaro Maria Teresa, Veroux Massimiliano
Dipartimento di Scienze Chirurgiche, Trapianti d'Organo e Tecnologie Avanzate UO Clinicizzata di Endocrinochirurgia, POU Garibaldi, Catania.
Chir Ital. 2006 Jan-Feb;58(1):105-11.
Cancer in a thyroglossal duct cyst is uncommon (incidence: approximately 1%). There are about 250 reported cases in the literature, most of which are papillary cancers or, less frequently, squamous or follicular carcinomas. The preoperative diagnosis of thyroglossal duct cyst carcinoma may be facilitated by an ultrasound neck examination or fine needle aspiration cytology (FNAc). As reported in the literature, however, the diagnosis is often obtained only at histopathological examination. We describe a case of a 43-year-old male patient with a papillary carcinoma in an isthmic thyroglossal duct cyst. Ultrasound of the neck demonstrated a nodular hypo-anechogenic cystic neoformation of the isthmus of the thyroid, while Fnac was not diagnostic. An isthmectomy of the thyroid was initially performed. Frozen examination of the cystic lesion revealed a papillary carcinoma in the thyroglossal duct cyst. A total thyroidectomy with central lymphectomy was therefore performed. Carcinoma in the thyroglossal duct has a low mortality (5-year mortality: < 2%), but a long-term follow-up is mandatory, due to the low, short-and medium-term recurrence rate.
甲状舌管囊肿癌变并不常见（发病率约为1%）。文献报道的病例约有250例，其中大多数为乳头状癌，鳞状或滤泡状癌则较少见。颈部超声检查或细针穿刺细胞学检查（FNAc）可能有助于术前诊断甲状舌管囊肿癌。然而，正如文献报道的那样，通常只有在组织病理学检查时才能确诊。我们描述了一例43岁男性患者，其峡部甲状舌管囊肿内有乳头状癌。颈部超声显示甲状腺峡部有一个结节状低回声囊性新生物，而FNAc检查未能明确诊断。最初进行了甲状腺峡部切除术。对囊性病变进行冰冻检查发现甲状舌管囊肿内有乳头状癌。因此，进行了全甲状腺切除术及中央区淋巴结清扫术。甲状舌管癌的死亡率较低（5年死亡率<2%），但由于其低、短期和中期复发率，长期随访是必要的。
