ADAM11基因缺陷小鼠的伤害性反应改变。
Altered nociceptive response in ADAM11-deficient mice.
作者信息
Takahashi Eiki, Sagane Koji, Nagasu Takeshi, Kuromitsu Junro
机构信息
Tsukuba Research Laboratory, Eisai Co. Ltd., 5-1-3, Tokodai, Tsukuba, Ibaraki, 300-2635, Japan.
出版信息
Brain Res. 2006 Jun 30;1097(1):39-42. doi: 10.1016/j.brainres.2006.04.043. Epub 2006 May 26.
Mice that lack A Disintegrin And Metalloprotease 11 (ADAM11) protein showed normal responses to stimuli in the von Frey test and the hot plate test, but showed reduced responses in the formalin paw test and acetic acid writhing test. Our results indicate that the cell adhesion-related molecule ADAM11 may play a role in pain transmission and in inflammatory regulation mechanisms underlying changes in the threshold for pain perception.
缺乏解整合素金属蛋白酶11（ADAM11）蛋白的小鼠在von Frey试验和热板试验中对刺激的反应正常，但在福尔马林足试验和醋酸扭体试验中反应减弱。我们的结果表明，细胞黏附相关分子ADAM11可能在疼痛传递以及疼痛感知阈值变化所潜在的炎症调节机制中发挥作用。
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