Malka Florence, Lombès Anne, Rojo Manuel
INSERM U582, Institut de Myologie, Groupe Hospitalier Pitié-Salpêtrière, Université Pierre et Marie Curie, IFR14, 47, boulevard de l'Hôpital, 75651 Paris cedex 13, France.
Biochim Biophys Acta. 2006 May-Jun;1763(5-6):463-72. doi: 10.1016/j.bbamcr.2006.04.001. Epub 2006 Apr 20.
Eukaryotic cells contain numerous copies of the mitochondrial genome (from 50 to 100 copies in the budding yeast to some thousands in humans) that localize to numerous intramitochondrial nucleoprotein complexes called nucleoids. The transmission of mitochondrial DNA differs significantly from that of nuclear genomes and depends on the number, molecular composition and dynamic properties of nucleoids and on the organization and dynamics of the mitochondrial compartment. While the localization, dynamics and protein composition of mitochondrial DNA nucleoids begin to be described, we are far from knowing all mechanisms and molecules mediating and/or regulating these processes. Here, we review our current knowledge on vertebrate nucleoids and discuss similarities and differences to nucleoids of other eukaryots.
真核细胞含有多个线粒体基因组拷贝（从芽殖酵母中的50到100个拷贝到人类中的数千个拷贝），这些拷贝定位于众多称为类核的线粒体内核蛋白复合物中。线粒体DNA的传递与核基因组的传递有显著差异，并且取决于类核的数量、分子组成和动态特性以及线粒体区室的组织和动态。虽然线粒体DNA类核的定位、动态和蛋白质组成开始得到描述，但我们对介导和/或调节这些过程的所有机制和分子还知之甚少。在这里，我们综述了我们目前对脊椎动物类核的认识，并讨论了与其他真核生物类核的异同。
