Kabi F, Mkinsi O, Zrigui J
Service de Rhumatologie, CHU Ibn-Rochd, Casablanca, Maroc.
Rev Med Interne. 2006 Jul;27(7):558-60. doi: 10.1016/j.revmed.2006.04.005. Epub 2006 May 15.
Pregnancy-associated osteoporosis is a rare disorder and its pathophysiology remains unknown. EXEGISIS: We report a case of pregnancy-associated osteoporosis in a 27-year-old primiparous patient, revealed by acute lumbar pain and a right costal pain during the last month of pregnancy. The standard radiographs showed multiple vertebral compression fracture and a 10th rib fracture. The diagnosis of osteoporosis was established by osteodensitometry. Diagnostic work-up excluded a secondary osteoporosis, and the outcome was favourable with an increase of bone mineral density after 2 years of treatment with calcium, vitamin D and alendronate 10 mg/j.
Although rare, diagnosis of pregnancy-associated osteoporosis should be suspected when thoracic or lumbar spine pain occur during pregnancy or in the post-partum period as it can lead to vertebral or peripheral fractures.
妊娠相关性骨质疏松是一种罕见疾病,其病理生理学仍不清楚。
我们报告一例27岁初产妇的妊娠相关性骨质疏松病例,该患者在妊娠最后一个月出现急性腰痛和右肋疼痛。标准X线片显示多发椎体压缩性骨折和第10肋骨骨折。通过骨密度测定确诊为骨质疏松。诊断性检查排除了继发性骨质疏松,经钙、维生素D和阿仑膦酸钠10毫克/日治疗2年后骨密度增加,预后良好。
尽管罕见,但在妊娠期间或产后出现胸腰椎疼痛时应怀疑妊娠相关性骨质疏松的诊断,因为它可导致椎体或周围骨折。