Klumpp Anja, Trautmann Thomas, Markert Michael, Guth Brian
Department of Drug Discovery Support, General Pharmacology Group, Boehringer Ingelheim Pharma GmbH & Co. KG, Germany.
J Pharmacol Toxicol Methods. 2006 Sep-Oct;54(2):141-9. doi: 10.1016/j.vascn.2006.03.010. Epub 2006 Apr 15.
The objective of this study was to test the influence of housing conditions on hemodynamics during cardiovascular general pharmacological studies. Our goal was to optimize both the quality of the data through an optimization of the physiological conditions, as well as to ensure the dog's well-being in general pharmacological studies.
Two groups of four dogs were equipped with radiotelemetry transmitters and continuously monitored in two different housing models. Model I consisted of 4 cages, two on each site of a corridor. Model II consisted of 4 cages positioned in a row, where the bordering cages were not separated with a metal plate. The physiological status of the dogs in the different housing models was based on the frequency of vocalizations and the average resting heart rate, as well as video monitoring.
The housing arrangement during the study had a remarkable effect on the hemodynamics measured. The hemodynamic parameters were best when the dogs were housed with their usual run mate. In this setting, they have impressively low average heart rates of about 60 bpm during the entire study, was associated with fewer vocalizations.
This study demonstrated that the quality of the acquired cardiovascular data for conscious dogs is dependent on the pen configuration and group make-up during a study.
本研究的目的是在心血管系统一般药理学研究中测试饲养条件对血流动力学的影响。我们的目标是通过优化生理条件来提高数据质量，并确保在一般药理学研究中狗的健康。
两组，每组四只狗，配备无线电遥测发射器，并在两种不同的饲养模式下进行连续监测。模式I由4个笼子组成，走廊两侧各有两个。模式II由4个排成一排的笼子组成，相邻的笼子之间没有用金属板隔开。不同饲养模式下狗的生理状态基于发声频率、平均静息心率以及视频监测。
研究期间的饲养安排对所测量的血流动力学有显著影响。当狗与它们通常的同伴一起饲养时，血流动力学参数最佳。在这种情况下，它们在整个研究期间的平均心率低至约60次/分钟，令人印象深刻，且发声较少。
本研究表明，清醒狗的心血管数据质量取决于研究期间的围栏配置和分组情况。
