Shiraishi Koji, Naito Katsusuke
Department of Urology, Yamaguchi University School of Medicine, Yamaguchi, Japan.
Fertil Steril. 2006 Jul;86(1):233-5. doi: 10.1016/j.fertnstert.2005.12.022. Epub 2006 May 30.
Increasing evidence suggests that testes with varicocele are exposed to oxidative stress (OS) with deterioration in spermatogenesis; however, the relationship between testicular OS and outcome after varicocelectomy is poorly understood. Levels of testicular 4-hydroxy-2-nonenal modified proteins, an OS marker, were significantly higher in responders than in nonresponders, suggesting that varicocelectomy reduces OS in testis.
越来越多的证据表明，患有精索静脉曲张的睾丸会受到氧化应激（OS）的影响，精子发生会恶化；然而，睾丸氧化应激与精索静脉曲张切除术后结果之间的关系却知之甚少。作为氧化应激标志物的睾丸4-羟基壬烯醛修饰蛋白水平在有反应者中显著高于无反应者，这表明精索静脉曲张切除术可降低睾丸中的氧化应激。
