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一氧化氮有助于年轻的SJL/J小鼠抵抗实验性自身免疫性脑脊髓炎。

Nitric oxide contributes to the resistance of young SJL/J mice to experimental autoimmune encephalomyelitis.

作者信息

Staykova Maria A, Fordham Susan A, Bartell Gavin J, Cowden William B, Willenborg David O

机构信息

Neurosciences Research Unit, The Canberra Hospital, Canberra, and The John Curtin School of Medical Research, Australian National University, Australia.

出版信息

J Neuroimmunol. 2006 Jul;176(1-2):1-8. doi: 10.1016/j.jneuroim.2006.03.015. Epub 2006 May 30.

DOI:10.1016/j.jneuroim.2006.03.015
PMID:16730804
Abstract

EAE development in SJL/J mice is age and sex dependent: young males are EAE resistant; females and adult males are EAE susceptible. By studying splenocytes' IFNgamma and NO production and the induction or the suppression of actively induced EAE by manipulating NO systemic levels, we provide evidence that the failure of young male SJL/J mice to develop EAE lies in the activation of the innate immune system by the immunising stimulus.

摘要

SJL/J小鼠的实验性自身免疫性脑脊髓炎（EAE）发展具有年龄和性别依赖性：年轻雄性小鼠对EAE具有抗性；雌性和成年雄性小鼠对EAE易感。通过研究脾细胞的γ干扰素和一氧化氮（NO）产生情况，以及通过操纵全身NO水平对主动诱导的EAE进行诱导或抑制，我们提供了证据表明年轻雄性SJL/J小鼠不能发展EAE在于免疫刺激激活了先天免疫系统。

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