从猪肠道分离出的胰腺分泌型胰蛋白酶抑制剂（PSTI）。对胰岛素和生长抑素释放的影响。

Pancreatic secretory trypsin inhibitor (PSTI) isolated from pig intestine. Influence on insulin and somatostatin release.

作者信息

Agerberth B, Ostenson C G, Efendic S, Jörnvall H

机构信息

Department of Biochemistry II, Karolinska Institutet, Stockholm, Sweden.

出版信息

FEBS Lett. 1991 Apr 9;281(1-2):227-30. doi: 10.1016/0014-5793(91)80399-n.

DOI:10.1016/0014-5793(91)80399-n

PMID:1673102

Abstract

Upon investigation of pig intestinal peptides for effects on the release of endocrine hormones from the isolated perfused rat pancreas, we reported earlier that glucose-stimulated insulin release was inhibited by PEC-60, a peptide with marked sequence similarity to PSTI (pancreatic secretory trypsin inhibitor). Continuing this study we found a polypeptide, which inhibited glucose-induced insulin release but enhanced glucose-induced somatostatin secretion. Determination of the amino acid sequence of this polypeptide revealed that it is identical to that of PSTI. Thus, PSTI modulates islet hormone release.

摘要

在研究猪肠肽对离体灌注大鼠胰腺内分泌激素释放的影响时，我们先前报道，与胰腺分泌性胰蛋白酶抑制剂（PSTI）具有显著序列相似性的肽PEC - 60可抑制葡萄糖刺激的胰岛素释放。继续这项研究，我们发现了一种多肽，它抑制葡萄糖诱导的胰岛素释放，但增强葡萄糖诱导的生长抑素分泌。对该多肽氨基酸序列的测定表明，它与PSTI的序列相同。因此，PSTI可调节胰岛激素的释放。