Hsia Tain-Yen, Gruber Peter J
Division of Cardiothoracic Surgery, The Children's Hospital of Philadelphia, Pennsylvania 19104, USA.
Ann Thorac Surg. 2006 Jun;81(6):S2381-8. doi: 10.1016/j.athoracsur.2006.02.074.
Advances in cardiopulmonary bypass and surgical techniques have led to progress in the early repair of congenital heart defects in children. However, as increasing numbers survive their initial cardiac operation, an awareness is emerging that significant early and late neurologic morbidities continue to complicate otherwise successful operative repairs. Adverse neurologic outcomes after neonatal cardiac surgery are multifactorial and relate to both fixed and modifiable mechanisms. The purpose of this review is to (1) review mechanisms of brain injury after neonatal cardiopulmonary bypass, (2) examine risk factors, and (3) speculate on how investigations may improve our understanding of neurologic injury.
体外循环和外科技术的进步推动了儿童先天性心脏缺陷早期修复的进展。然而，随着越来越多的患儿在首次心脏手术后存活下来，人们逐渐意识到，严重的早期和晚期神经病变仍然使原本成功的手术修复变得复杂。新生儿心脏手术后不良的神经学后果是多因素的，与固定和可改变的机制都有关。本综述的目的是：（1）回顾新生儿体外循环后脑损伤的机制；（2）研究风险因素；（3）推测研究如何能增进我们对神经损伤的理解。
