口腔大疱性淀粉样变：一种罕见的临床表现及文献综述

Bullous amyloidosis of the oral cavity: a rare clinical presentation and review.

作者信息

Stoopler Eric T, Alawi Faizan, Laudenbach Joel M, Sollecito Thomas P

机构信息

Department of Oral Medicine, School of Dental Medicine, University of Pennsylvania, 240 South 40th Street, Philadelphia, PA 19104, USA.

出版信息

Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2006 Jun;101(6):734-40. doi: 10.1016/j.tripleo.2006.01.003. Epub 2006 Apr 24.

DOI:10.1016/j.tripleo.2006.01.003

PMID:16731392

Abstract

Bullous amyloidosis (BA) is a rare cutaneous manifestation primarily of systemic amyloidosis, a disease in which abnormal proteinaceous material is formed and deposited in response to inflammatory conditions and plasma cell dyscrasias. Hemorrhagic bullae indicative of BA are usually associated with purpura and may be the initial clinical signs of systemic amyloidosis or monoclonal gammopathies, such as multiple myeloma and Waldenstrom's macroglobulinemia. Bullous amyloidosis of the oral cavity is highly uncommon and can mimic other vesiculobullous lesions of the oral mucosa. This article highlights an unusual case of oral BA and reviews important aspects of the disease.

摘要

大疱性淀粉样变（BA）是系统性淀粉样变的一种罕见皮肤表现，系统性淀粉样变是一种因炎症状态和浆细胞发育异常而形成并沉积异常蛋白质物质的疾病。提示BA的出血性大疱通常与紫癜相关，可能是系统性淀粉样变或单克隆丙种球蛋白病（如多发性骨髓瘤和华氏巨球蛋白血症）的初始临床体征。口腔大疱性淀粉样变极为罕见，可酷似口腔黏膜的其他水疱大疱性病变。本文重点介绍一例不寻常的口腔BA病例，并综述该疾病的重要方面。