额叶皮层微刺激引起的视觉感受野变化。

Changes in visual receptive fields with microstimulation of frontal cortex.

作者信息

Armstrong Katherine M, Fitzgerald Jamie K, Moore Tirin

机构信息

Department of Neurobiology, Stanford University School of Medicine, California 94305, USA.

出版信息

Neuron. 2006 Jun 1;50(5):791-8. doi: 10.1016/j.neuron.2006.05.010.

DOI:10.1016/j.neuron.2006.05.010

PMID:16731516

Abstract

The influence of attention on visual cortical neurons has been described in terms of its effect on the structure of receptive fields (RFs), where multiple stimuli compete to drive neural responses and ultimately behavior. We stimulated the frontal eye field (FEF) of passively fixating monkeys and produced changes in V4 responses similar to known effects of voluntary attention. Subthreshold FEF stimulation enhanced visual responses at particular locations within the RF and altered the interaction between pairs of RF stimuli to favor those aligned with the activated FEF site. Thus, we could influence which stimulus drove the responses of individual V4 neurons. These results suggest that spatial signals involved in saccade preparation are used to covertly select among multiple stimuli appearing within the RFs of visual cortical neurons.

摘要

注意力对视觉皮层神经元的影响已根据其对感受野（RFs）结构的作用进行了描述，在感受野中，多个刺激相互竞争以驱动神经反应并最终影响行为。我们刺激了被动注视猴子的额叶眼区（FEF），并在V4反应中产生了类似于已知的自愿注意力效应的变化。阈下FEF刺激增强了感受野内特定位置的视觉反应，并改变了感受野刺激对之间的相互作用，从而有利于与激活的FEF位点对齐的刺激。因此，我们可以影响哪个刺激驱动单个V4神经元的反应。这些结果表明，参与扫视准备的空间信号被用于在视觉皮层神经元感受野内出现的多个刺激之间进行隐蔽选择。