ACE-it：一种用于全基因组整合基因剂量和RNA表达数据的工具。
ACE-it: a tool for genome-wide integration of gene dosage and RNA expression data.
作者信息
van Wieringen Wessel N, Belien Jeroen A M, Vosse Sjoerd J, Achame Eskeatnaf M, Ylstra Bauke
机构信息
Department of Mathematics, Vrije Universiteit De Boelelaan 1081, 1081 HV, Amsterdam, The Netherlands.
出版信息
Bioinformatics. 2006 Aug 1;22(15):1919-20. doi: 10.1093/bioinformatics/btl269. Epub 2006 May 26.
SUMMARY
We describe a tool, called ACE-it (Array CGH Expression integration tool). ACE-it links the chromosomal position of the gene dosage measured by array CGH to the genes measured by the expression array. ACE-it uses this link to statistically test whether gene dosage affects RNA expression.
AVAILABILITY
ACE-it is freely available at http://ibivu.cs.vu.nl/programs/acewww/.
摘要
我们描述了一种名为ACE-it（阵列比较基因组杂交表达整合工具）的工具。ACE-it将通过阵列比较基因组杂交测量的基因剂量的染色体位置与通过表达阵列测量的基因联系起来。ACE-it利用这种联系进行统计测试，以确定基因剂量是否影响RNA表达。
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