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金珠植入治疗髋关节发育不良犬疼痛缓解效果的双盲、安慰剂对照试验。

Double-blind, placebo-controlled trial of the pain-relieving effects of the implantation of gold beads into dogs with hip dysplasia.

作者信息

Jaeger G T, Larsen S, Søli N, Moe L

机构信息

Department of Companion Animal Clinical Sciences, Norwegian School of Veterinary Science, PO Box 8146 Dep, N-0033 Oslo, Norway.

出版信息

Vet Rec. 2006 May 27;158(21):722-6. doi: 10.1136/vr.158.21.722.

Abstract

Seventy-eight dogs with pain due to hip dysplasia were studied in a controlled, double-blind clinical trial to evaluate gold bead implantation as a pain-relieving treatment. The dogs were randomly assigned to two groups, 36 in the gold implantation group and 42 in the placebo group. Both groups were treated equally regarding anaesthesia, hair clipping and penetration of the skin with the same type of needle. The gold implantation group had small pieces of 24 carat gold inserted through needles at five different acupuncture points and the placebo group had the skin penetrated at five non-acupuncture points so as to avoid any possible effect of stimulating the acupuncture points. A certified veterinary acupuncturist marked the points, and two surgeons performed the implantations according to a randomisation code made in advance. After 14 days, three months and six months, the owners assessed the overall effect of the treatments by answering a questionnaire, and the same veterinarian examined each dog and evaluated its degree of lameness by examining videotaped footage of it walking and trotting. The treatment was blinded for both the owners and the veterinarian. There were significantly greater improvements in mobility and greater reductions in the signs of pain in the dogs treated with gold implantation than in the placebo group. The veterinarian's and the owners' assessments corresponded well.

摘要

在一项对照双盲临床试验中,对78只因髋关节发育不良而疼痛的犬进行了研究,以评估金珠植入作为一种缓解疼痛的治疗方法。这些犬被随机分为两组,金植入组36只,安慰剂组42只。两组在麻醉、剪毛以及使用同类型针头穿透皮肤方面接受相同的处理。金植入组通过针头在五个不同的穴位插入24克拉的小金片,安慰剂组在五个非穴位点穿透皮肤,以避免刺激穴位可能产生的任何影响。一名经过认证的兽医针灸师标记穴位,两名外科医生根据预先制定的随机编码进行植入操作。在14天、三个月和六个月后,犬主通过回答问卷评估治疗的总体效果,同一名兽医检查每只犬,并通过查看其行走和小跑的录像来评估其跛行程度。犬主和兽医对治疗情况均不知情。与安慰剂组相比,接受金植入治疗的犬在活动能力方面有显著更大的改善,疼痛迹象也有更大程度的减轻。兽医和犬主的评估结果相当一致。

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