Teixeira Lívia R, Luna Stelio P L, Matsubara Lídia M, Cápua Maria L B, Santos Bianca P C R, Mesquita Luciane R, Faria Luis G, Agostinho Felipe S, Hielm-Björkman Anna
J Am Vet Med Assoc. 2016 Nov 1;249(9):1031-1039. doi: 10.2460/javma.249.9.1031.
OBJECTIVE To evaluate pain intensity and kinetic variables in dogs with hip dysplasia (HD) treated with acupuncture, carprofen, or a placebo. DESIGN Randomized, controlled clinical study. ANIMALS 54 HD-affected dogs and 16 healthy dogs. PROCEDURES Seven HD-affected dogs were removed from the study. Dogs with HD were treated in a blinded manner for 30 days with acupuncture (once weekly for 5 sessions; n = 15), carprofen (4.4 mg/kg [2.0 mg/lb], PO, q 24 h; n = 16), or placebo capsules containing lactose (1 mg/kg [0.45 mg/lb], PO, q 24 h; n = 16). Dogs were evaluated 2 weeks and immediately before (baseline) and 2, 4, and 6 weeks after the onset of treatment. Owners evaluated the dogs' pain intensity with 2 validated questionnaires and a visual analogue scale (VAS) for pain and evaluated degree of lameness with a VAS for locomotion. Kinetics of the hind limbs were also evaluated. Sixteen HD-free dogs were used to assess the evaluation protocol. RESULTS Owners' assessments revealed that outcomes of the 3 treatments did not differ significantly. The Canine Brief Pain Inventory and VAS pain intensity assessments were decreased from baseline at weeks 4 and 6, respectively, but only in acupuncture-treated dogs. The locomotion VAS values were decreased at week 4 in acupuncture-treated and carprofen-treated dogs. Kinetic evaluation findings did not differ among the groups or over time. CONCLUSIONS AND CLINICAL RELEVANCE Neither acupuncture nor carprofen was significantly different from placebo. Acupuncture and carprofen reduced the degree of subjectively evaluated lameness, and acupuncture was associated with a decrease in validated chronic pain scores.
目的 评估接受针灸、卡洛芬或安慰剂治疗的髋关节发育不良（HD）犬的疼痛强度和动力学变量。 设计 随机对照临床研究。 动物 54 只患HD的犬和16只健康犬。 程序 7只患HD的犬被排除在研究之外。患HD的犬以盲法接受治疗30天，治疗方式为针灸（每周1次，共5次；n = 15）、卡洛芬（4.4 mg/kg [2.0 mg/lb]，口服，每24小时1次；n = 16）或含乳糖的安慰剂胶囊（1 mg/kg [0.45 mg/lb]，口服，每24小时1次；n = 16）。在治疗开始前（基线）、治疗开始后2周、4周和6周对犬进行评估。主人使用2份经过验证的问卷和疼痛视觉模拟量表（VAS）评估犬的疼痛强度，并使用运动VAS评估跛行程度。还评估了后肢的动力学情况。使用16只无HD的犬评估评估方案。 结果 主人的评估显示，3种治疗的结果无显著差异。犬简明疼痛量表和VAS疼痛强度评估分别在第4周和第6周时较基线水平降低，但仅在接受针灸治疗的犬中出现这种情况。在接受针灸治疗和卡洛芬治疗的犬中，运动VAS值在第4周时降低。各治疗组之间以及不同时间的动力学评估结果无差异。 结论及临床意义 针灸和卡洛芬与安慰剂相比均无显著差异。针灸和卡洛芬降低了主观评估的跛行程度，且针灸与经过验证的慢性疼痛评分降低有关。
