老年抑郁症急性治疗期间，睡眠障碍和焦虑症状与核心情绪症状相比的改善速度。
Speed of improvement in sleep disturbance and anxiety compared with core mood symptoms during acute treatment of depression in old age.
作者信息
Dombrovski Alexandre Y, Blakesley-Ball Richard E, Mulsant Benoit H, Mazumdar Sati, Houck Patricia R, Szanto Katalin, Reynolds Charles F
机构信息
Western Psychiatric Institute and Clinic, Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
出版信息
Am J Geriatr Psychiatry. 2006 Jun;14(6):550-4. doi: 10.1097/01.JGP.0000218325.76196.d1.
OBJECTIVES
The objective of this study was to examine the relative speed of improvement in sleep disturbance and anxiety symptoms compared with core mood symptoms in acute treatment of late-life major depression.
METHOD
The authors conducted secondary analysis of acute treatment data in 470 older patients treated in three federally funded studies. The authors compared rates of improvement in three Hamilton Rating Scale for Depression symptom clusters after stratification by study.
RESULTS
Anxiety symptoms improved more slowly with antidepressant monotherapy and with combined pharmacotherapy/psychotherapy, whereas sleep symptoms improved at a similar rate as core mood symptoms.
CONCLUSIONS
Anxiety symptoms tend to persist in patients with late-life depression.
目的
本研究的目的是在老年重度抑郁症的急性治疗中，检验睡眠障碍和焦虑症状相较于核心情绪症状改善的相对速度。
方法
作者对在三项由联邦政府资助的研究中接受治疗的470名老年患者的急性治疗数据进行了二次分析。作者在按研究分层后，比较了汉密尔顿抑郁量表三个症状群的改善率。
结果
抗抑郁药单药治疗以及药物治疗/心理治疗联合使用时，焦虑症状改善较慢，而睡眠症状改善速度与核心情绪症状相似。
结论
老年抑郁症患者的焦虑症状往往会持续存在。
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