戊巴比妥对完整和肾上腺切除大鼠基础及乙醚刺激的促肾上腺皮质激素分泌的影响。

The effect of pentobarbital on basal and ether-stimulated ACTH secretion in intact and adrenalectomized rats.

作者信息

Greer M A, Allen C F

出版信息

Neuroendocrinology. 1975;17(3):258-64. doi: 10.1159/000122361.

Abstract

Pentobarbital in a dose of 3.5 mg/100 g b.w. did not suppress the high basal a.m. levels of plasma ACTH in adrenalectomized male rats. In both intact and adrenalectomized rats prior administration of the drug slightly depressed the rise in plasma ACTH induced by 2.5 min of ether inhalation, but this depression is of questionable statistical significance.

摘要

剂量为3.5毫克/100克体重的戊巴比妥并未抑制去肾上腺雄性大鼠上午较高的血浆促肾上腺皮质激素基础水平。在完整大鼠和去肾上腺大鼠中，预先给药该药物会轻微抑制由吸入乙醚2.5分钟诱导的血浆促肾上腺皮质激素升高，但这种抑制作用的统计学意义存疑。