自身免疫调节因子（Aire）控制自然杀伤T细胞（iNKT细胞）的发育和成熟。

The autoimmune regulator (Aire) controls iNKT cell development and maturation.

作者信息

Mi Qing-Sheng, Deng Zhong-Bin, Joshi Sunil K, Wang Zai-Zhao, Zhou Li, Eckenrode Sarah, Joshi Ratanmani, Ly Dalam, Yi Bing, Delovitch Terry L, She Jin-Xiong

机构信息

Center for Biotechnology and Genomic Medicine, Medical College of Georgia, 1120 15th Street, Augusta, Georgia 30912, USA.

出版信息

Nat Med. 2006 Jun;12(6):624-6. doi: 10.1038/nm1424. Epub 2006 May 28.

DOI:10.1038/nm1424

PMID:16732280

Abstract

The mechanism underlying the autoimmune polyglandular syndrome type-1 (APS1) has been attributed to defective T-cell negative selection resulting from reduced expression and presentation of autoantigens in thymic medullary epithelial cells (MECs). It has also been postulated that Aire is involved in development of regulatory T cells, although supporting evidence is lacking. Here we show that expression of Aire in MECs is required for development of iNKT cells, suggesting a role for iNKT cells in APS1.

摘要

1型自身免疫性多腺体综合征（APS1）的潜在机制被认为是由于胸腺髓质上皮细胞（MECs）中自身抗原的表达和呈递减少导致T细胞阴性选择缺陷。也有人推测自身免疫调节因子（Aire）参与调节性T细胞的发育，尽管缺乏支持证据。在此我们表明，MECs中Aire的表达是不变自然杀伤T细胞（iNKT细胞）发育所必需的，这表明iNKT细胞在APS1中发挥作用。