因遗传疾病导致男性不育时的精子冷冻保存。

Sperm cryopreservation in male infertility due to genetic disorders.

作者信息

Krausz Csilla, Forti Gianni

机构信息

Andrology Unit, Department of Clinical Physiopathology, Viale Pieraccini, 6, Firenze, Italy.

出版信息

Cell Tissue Bank. 2006;7(2):105-12. doi: 10.1007/s10561-005-1967-9.

DOI:10.1007/s10561-005-1967-9

PMID:16732413

Abstract

Certain chromosomal and genetic anomalies, such as Klinefelter syndrome (47,XXY) and Y chromosome microdeletions, have been reported as potential causes of a progressive impairment of spermatogenesis. In these cases cryoconservation of ejaculated or testicular sperm represent a valuable tool for the preservation of fertility. However, dealing with genetic disorders, the transmission of genetic anomalies has to be taken into consideration. It is therefore important to be aware about the clinical importance and the related genetic risks of these anomalies. In this article we describe the clinical significance of these diseases.

摘要

某些染色体和基因异常，如克兰费尔特综合征（47,XXY）和Y染色体微缺失，已被报道为精子发生进行性损害的潜在原因。在这些情况下，冷冻保存射出的精子或睾丸精子是保存生育能力的一项重要手段。然而，对于遗传性疾病，必须考虑遗传异常的传递。因此，了解这些异常的临床重要性和相关遗传风险非常重要。在本文中，我们描述了这些疾病的临床意义。