Forrester Mathias B, Merz Ruth D
Hawaii Birth Defects Program, Honolulu, Hawaii 96817-5157, USA.
Congenit Anom (Kyoto). 2006 Jun;46(2):76-80. doi: 10.1111/j.1741-4520.2006.00106.x.
The objective of this investigation was to identify the rates for specific birth defects among the offspring of Japanese mothers in Hawaii and compare them to rates among the offspring of white mothers. Cases were all infants and fetuses with any of 54 specific birth defects born to Japanese and white mothers identified by a population-based birth defects registry in Hawaii. The rates were calculated for both racial groups and comparisons made by calculating the rate ratio and 95% confidence interval. The rates among the offspring of Japanese mothers were substantially higher for four of the birth defects (pulmonary valve atresia and stenosis, anomalous pulmonary venous return, cleft lip with/without cleft palate, small intestinal atresia and stenosis) and substantially lower for five of the birth defects (pyloric stenosis, hypospadias and epispadias, renal agenesis and hypoplasia, obstructive genitourinary defect, syndactyly). After adjusting for maternal age, these significantly elevated or lower rates remained. Moreover, the rate was significantly higher among the offspring of Japanese mothers for anotia/microtia, tetralogy of Fallot, and persistent cloaca and significantly lower for transposition of great arteries. The rates for a number of specific birth defects differed between Japanese and white mothers in Hawaii.
本调查的目的是确定夏威夷日本母亲后代中特定出生缺陷的发生率，并将其与白人母亲后代的发生率进行比较。病例为夏威夷基于人群的出生缺陷登记处确定的日本和白人母亲所生的患有54种特定出生缺陷中任何一种的所有婴儿和胎儿。计算了两个种族群体的发生率，并通过计算率比和95%置信区间进行比较。日本母亲后代中，有四种出生缺陷（肺动脉瓣闭锁和狭窄、肺静脉异位回流、唇裂伴/不伴腭裂、小肠闭锁和狭窄）的发生率显著较高，有五种出生缺陷（幽门狭窄、尿道下裂和尿道上裂、肾缺如和发育不全、梗阻性泌尿生殖系统缺陷、并指/趾畸形）的发生率显著较低。在调整了母亲年龄后，这些显著升高或降低的发生率仍然存在。此外，日本母亲后代中无耳/小耳、法洛四联症和泄殖腔持续存在的发生率显著较高，而大动脉转位的发生率显著较低。夏威夷日本和白人母亲所生后代中，许多特定出生缺陷的发生率存在差异。
