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参与极化运输和轴突生长的驱动蛋白调节因子。

Regulators of kinesin involved in polarized trafficking and axon outgrowth.

作者信息

Luo Shuo, Nonet Michael L

机构信息

Department of Anatomy and Neurobiology, Washington University School of Medicine, 660 S, Euclid Avenue, Saint Louis, MO 63110, USA.

出版信息

J Biol. 2006;5(4):8. doi: 10.1186/jbiol41. Epub 2006 May 25.

DOI:10.1186/jbiol41
PMID:16732897
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1561583/
Abstract

Proteins such as UNC-76 that associate with kinesin motors are important in directing neurite extension. A small Caenorhabditis elegans coiled-coil protein, UNC-69, has now been shown to interact with UNC-76 and to be involved in axonal (but not dendritic) transport and outgrowth, as well as synapse formation.

摘要

诸如UNC-76这类与驱动蛋白马达相关的蛋白质在引导神经突延伸过程中起着重要作用。现已证明，一种小型秀丽隐杆线虫卷曲螺旋蛋白UNC-69可与UNC-76相互作用，并参与轴突（而非树突）运输、生长以及突触形成。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e901/1561583/ef01892b3799/jbiol41-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e901/1561583/ef01892b3799/jbiol41-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e901/1561583/ef01892b3799/jbiol41-1.jpg

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本文引用的文献

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J Biol. 2006;5(4):9. doi: 10.1186/jbiol39. Epub 2006 May 25.
2
A change in the selective translocation of the Kinesin-1 motor domain marks the initial specification of the axon.驱动蛋白-1运动结构域选择性易位的变化标志着轴突的初始特化。
Neuron. 2006 Mar 16;49(6):797-804. doi: 10.1016/j.neuron.2006.02.005.
3
The kinesin-associated protein UNC-76 is required for axonal transport in the Drosophila nervous system.
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BMC Dev Biol. 2008 Apr 9;8:38. doi: 10.1186/1471-213X-8-38.
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Mol Biol Cell. 2003 Aug;14(8):3356-65. doi: 10.1091/mbc.e02-12-0800. Epub 2003 May 3.
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Trafficking of signaling modules by kinesin motors.驱动蛋白分子马达对信号模块的运输
J Cell Sci. 2003 Jun 1;116(Pt 11):2125-35. doi: 10.1242/jcs.00488.
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