Xing Li-min, Shao Zong-hong, Liu Hong, Shi Jun, Bai Jie, Wang Hua-quan, Tu Mei-feng, Sun Juan
Institute of Hematology and Blood Diseases Hospital, CAMS & PUMC, Tianjin 300020, China.
Zhonghua Xue Ye Xue Za Zhi. 2006 Jan;27(1):42-4.
To study the clinical characteristics of autoimmune hemolytic anemia (AIHA) with both warm and cold autoantibodies.
Clinical and laboratory characteristics of 23 cases of AIHA with both warm and cold autoantibodies admitted to our hospital between January 1994 and April 2004 were analyzed retrospectively.
In comparison with the AIHA patients with both warm and cold autoantibodies in the 1980s, the present patients showed the following features: The proportion of this kind AIHA in all AIHA patients increased from 17.6% to 22.1%. There were more females, more primary cases (73.9%), more mixed subtypes of autoantibodies and more of IgM (56.5%). The hemolysis was related with thermal amplitude of autoantibodies and quantity of complement. The response to cortisone and other immunosuppressive drugs was good. The relapse rate was 77.8% in a median follow-up time of 4 months.
AIHA with both warm and cold autoantibodies is related with the type and thermal amplitude of the autoantibody and the activation of complement. It can be treated effectively with combined immunosuppressive therapy, but the relapse rate is high.
研究伴有温冷自身抗体的自身免疫性溶血性贫血（AIHA）的临床特征。
回顾性分析1994年1月至2004年4月我院收治的23例伴有温冷自身抗体的AIHA患者的临床及实验室特征。
与20世纪80年代伴有温冷自身抗体的AIHA患者相比，目前的患者具有以下特点：此类AIHA在所有AIHA患者中的比例从17.6%增至22.1%。女性更多，原发性病例更多（73.9%），自身抗体混合亚型更多，IgM更多（56.5%）。溶血与自身抗体的热幅度及补体数量有关。对皮质激素及其他免疫抑制药物反应良好。中位随访时间4个月时复发率为77.8%。
伴有温冷自身抗体的AIHA与自身抗体的类型和热幅度以及补体激活有关。联合免疫抑制治疗可有效治疗，但复发率高。
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