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用乙烯-乙烯醇共聚物(Onyx18)对颅内硬脑膜动静脉畸形进行经动脉栓塞术

[Transarterial embolisation of intracranial dural arteriovenous malformations with ethylene vinyl alcohol copolymer (Onyx18)].

作者信息

Toulgoat F, Mounayer C, Túlio Salles Rezende M, Piotin M, Spelle L, Lazzarotti G, Desal H, Moret J

机构信息

Service de Neuroradiologie Interventionnelle, Fondation Rothschild, 25-29 rue Manin, 75940 Paris Cedex 19.

出版信息

J Neuroradiol. 2006 Apr;33(2):105-14. doi: 10.1016/s0150-9861(06)77239-x.

Abstract

OBJECTIVE

To report our recent experience in transarterial embolisation of dural arteriovenous malformations (DAVM) using a new liquid embolic agent, Onyx18.

PATIENTS AND METHODS

6 patients were enrolled in this series. Clinical presentation was separated into 2 groups: aggressive (n=2), non aggressive (n=4). The DAVM was located at the superior sagittal sinus (n=1), at the transverse sinus (n=2), at the condylian canal (n=1), in the lesser sphenoid wing region (n=1), and in the tentorium region (n=1). The DAVM drained directly into a condylian or a cortical vein for three patients and into a venous sinus with cortical venous reflux for the three others. In this latter situation, the sinus was anatomically excluded from the normal brain venous drainage.

RESULTS

A full brain angiogram including both internal carotid arteries, both external carotid arteries and ipsilateral vertebral artery, was performed before and after each treatment. The feeder chosen after a selective catheterisation for Onyx18 injection was always meningeal. Each treatment consisted of a single Onyx injection after one unique feeder catheterisation. Complete anatomical exclusion of the DAVM was achieved and demonstrated by the post treatment angiogram in all cases. There was no clinical complication after the treatment.

CONCLUSION

Onyx18 used is a safe treatment for DAVMs. When its injection is performed in optimal conditions, it fills the total DAVM and its drainage vein or sinus after a single arterial feeder catheterisation.

摘要

目的

报告我们近期使用新型液体栓塞剂Onyx18经动脉栓塞治疗硬脑膜动静脉畸形(DAVM)的经验。

患者与方法

本系列纳入6例患者。临床表现分为两组:侵袭性(n = 2),非侵袭性(n = 4)。DAVM位于上矢状窦(n = 1)、横窦(n = 2)、髁管(n = 1)、蝶骨小翼区域(n = 1)和小脑幕区域(n = 1)。3例患者的DAVM直接引流至髁静脉或皮质静脉,另外3例引流至伴有皮质静脉反流的静脉窦。在后一种情况下,该静脉窦在解剖学上被排除在正常脑静脉引流之外。

结果

每次治疗前后均进行包括双侧颈内动脉、双侧颈外动脉和同侧椎动脉的全脑血管造影。经选择性插管后选择用于注射Onyx18的供血动脉均为脑膜动脉。每次治疗均在一次独特的供血动脉插管后进行单次Onyx注射。所有病例经治疗后的血管造影均显示DAVM完全在解剖学上被闭塞。治疗后无临床并发症。

结论

所使用的Onyx18是治疗DAVM的一种安全方法。在最佳条件下进行注射时,经单次动脉供血动脉插管后,它可填充整个DAVM及其引流静脉或静脉窦。

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