用于不对称转移氢化中高对映体控制的具有手性二胺活化剂的非手性二苯甲酮配体-铑配合物
Achiral benzophenone ligand-rhodium complex with chiral diamine activator for high enantiocontrol in asymmetric transfer hydrogenation.
作者信息
Mikami Koichi, Wakabayashi Kazuki, Yusa Yukinori, Aikawa Kohsuke
机构信息
Department of Applied Chemistry, Tokyo Institute of Technology, Tokyo, 152-8552, Japan.
出版信息
Chem Commun (Camb). 2006 Jun 14(22):2365-7. doi: 10.1039/b517585b. Epub 2006 May 3.
DOI:10.1039/b517585b
PMID:16733581
Abstract
The chirality of an achiral benzophenone-based rhodium complex can be controlled by chiral diamines to afford significantly high enantioselectivity in the catalytic asymmetric transfer hydrogenation of ketones (up to 99% ee, 99% yield).
摘要
一种基于二苯甲酮的非手性铑配合物的手性可通过手性二胺来控制，从而在酮的催化不对称转移氢化反应中实现显著的高对映选择性（对映体过量高达99%，产率99%）。
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