Terwindt G M, Haan J, Bax J J, de Bruijn S F T M, Ferrari M D
Leids Universitair Medisch Centrum, Albinusdreef 2, 2333 ZA Leiden.
Ned Tijdschr Geneeskd. 2006 May 13;150(19):1050-2.
The relationship between patent foramen ovale (PFO) and migraine is controversial. A common genetic background seems possible, but there is no evidence for a causal relationship. Despite the lack of evidence, PFO closure is recommended in many countries as a remedy for migraine. At present, PFO closure for migraine should only be carried out under strictly controlled clinical trial conditions.
卵圆孔未闭（PFO）与偏头痛之间的关系存在争议。共同的遗传背景似乎有可能，但尚无因果关系的证据。尽管缺乏证据，但在许多国家，卵圆孔未闭封堵术被推荐作为偏头痛的一种治疗方法。目前，偏头痛的卵圆孔未闭封堵术仅应在严格控制的临床试验条件下进行。
