一种用于高对映选择性不对称氢甲酰化反应的混合磷配体。
A hybrid phosphorus ligand for highly enantioselective asymmetric hydroformylation.
作者信息
Yan Yongjun, Zhang Xumu
机构信息
Department of Chemistry, The Pennsylvania State University, University Park, Pennsylvania 16802, USA.
出版信息
J Am Chem Soc. 2006 Jun 7;128(22):7198-202. doi: 10.1021/ja057065s.
PMID:16734472
Abstract
A new hybrid phosphorus ligand has been prepared starting from chiral NOBIN (2-amino-2'-hydroxy-1,1'-binaphthyl). Excellent enantioselectivities (up to 99% ee) have been achieved in the Rh-catalyzed asymmetric hydroformylations of styrene derivatives and vinyl acetate.
摘要
一种新的杂化磷配体已从手性NOBIN（2-氨基-2'-羟基-1,1'-联萘）开始制备。在铑催化的苯乙烯衍生物和醋酸乙烯酯的不对称氢甲酰化反应中，已实现了优异的对映选择性（高达99% ee）。
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