Siegel Melissa J, Finlay Jonathan L, Zacharoulis Stergios
Childrens Hospital Los Angeles, The Neural Tumos Program, Childrens Center for Cancer and Blood Diseases, Los Angeles, California, USA.
Expert Rev Neurother. 2006 May;6(5):765-79. doi: 10.1586/14737175.6.5.765.
CNS tumors are the most common solid tumor of childhood. This article will review current treatments for pediatric brain tumors; low-grade gliomas, high-grade gliomas, medulloblastomas and ependymomas. It will also highlight the treatments that are used for brain tumors in very young children and in children with recurrent brain tumors. The management of recurrent pediatric brain tumors unresponsive to standard therapy will be discussed. The agents used in this setting are mainly biological modifiers, which attempt to provide molecularly targeted therapy. Future directions of therapy for pediatric brain tumors are described. Future treatment paradigms will need to consider examining the use of multiple biological modifiers. Similarly, these agents will need to be examined in combination with cytotoxic chemotherapy. Finally, the future direction of pediatric neuro-oncology and the focus of the field as it battles pediatric brain tumors is discussed.
中枢神经系统肿瘤是儿童最常见的实体瘤。本文将综述儿童脑肿瘤的当前治疗方法；低级别胶质瘤、高级别胶质瘤、髓母细胞瘤和室管膜瘤。还将重点介绍用于非常年幼儿童和复发性脑肿瘤儿童的脑肿瘤治疗方法。将讨论对标准治疗无反应的复发性儿童脑肿瘤的管理。在此情况下使用的药物主要是生物调节剂，旨在提供分子靶向治疗。描述了儿童脑肿瘤治疗的未来方向。未来的治疗模式将需要考虑研究多种生物调节剂的使用。同样，这些药物需要与细胞毒性化疗联合使用进行研究。最后，讨论了儿童神经肿瘤学的未来方向以及该领域在对抗儿童脑肿瘤时的重点。
