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膀胱阴道瘘修补术后复发的预后因素

Prognostic factors of recurrence after vesicovaginal fistula repair.

作者信息

Ayed Mohsen, El Atat Rabii, Hassine Lotfi Ben, Sfaxi Mohamed, Chebil Mohamed, Zmerli Saadoun

机构信息

Department of Urology, Charles Nicolle Hospital, Tunis, Tunisia.

出版信息

Int J Urol. 2006 Apr;13(4):345-9. doi: 10.1111/j.1442-2042.2006.01308.x.

Abstract

PURPOSE

We evaluate the prognostic factors of recurrence in patients after the surgical repair of vesicovaginal fistula.

MATERIALS AND METHODS

From 1985 to 2002, 73 women with vesicovaginal fistula underwent late (> 3 months) surgical repair. A multivariate analysis of the data was performed with the EPI-INFO software. All P-values were two-sided, with odds ratio and 95% confidence intervals.

RESULTS

A total number of 73 patients underwent 97 procedures with a mean rate of 1.38 procedures/patient. The overall surgical success rate was 86.7%. Multivariate analysis demonstrated that recurrence was statistically significant for multiple fistulas (single vs two or more), fistula size (>10 mm), fistula type (Type I vs Type II), fistula etiology (obstetrical vs non-obstetrical) and the presence of urinary tract infection before the repair. Recurrence risk was fivefold higher for both the size and the type of the fistula, threefold higher for obstetrical etiology and 4.5-fold higher for multiple fistula. The interposition of flaps was a protective factor for recurrent cases. The surgical approach was not a significant prognostic factor of recurrence.

CONCLUSION

Successful closure of a vesicovaginal fistula requires an accurate and a timely repair using procedures that exploit basic surgical principles. Multiple fistula, size and type of the fistula, and obstetrical etiology were the recurrence risk factors. We recommend in all patients with multiple risk factors for recurrence, the interposition of flaps.

摘要

目的

我们评估膀胱阴道瘘手术修复术后患者复发的预后因素。

材料与方法

1985年至2002年,73例膀胱阴道瘘女性患者接受了延迟(>3个月)手术修复。使用EPI-INFO软件对数据进行多变量分析。所有P值为双侧,伴有比值比和95%置信区间。

结果

共有73例患者接受了97次手术,平均每位患者手术次数为1.38次。总体手术成功率为86.7%。多变量分析表明,对于多发瘘(单发与两个或更多)、瘘口大小(>10mm)、瘘口类型(I型与II型)、瘘口病因(产科与非产科)以及修复前存在尿路感染,复发具有统计学意义。瘘口大小和类型的复发风险高出五倍,产科病因高出三倍,多发瘘高出4.5倍。皮瓣置入是复发病例的保护因素。手术方式不是复发的显著预后因素。

结论

成功闭合膀胱阴道瘘需要采用运用基本外科原则的手术方法进行准确及时的修复。多发瘘、瘘口大小和类型以及产科病因是复发风险因素。我们建议对所有具有多个复发风险因素的患者置入皮瓣。

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