Weinreb David B, Desman Garrett T, Burstein David E, Dikman Steven H, Johnson Edward M
Department of Pathology, Mount Sinai School of Medicine, New York 10029, USA.
Int J Urol. 2006 Apr;13(4):439-41. doi: 10.1111/j.1442-2042.2006.01337.x.
Polyoma virus nephropathy (PVN) is a significant cause of renal allograft dysfunction in transplant patients. A 58-year-old male received a cadaveric renal transplant and 12 weeks later presented with fever, diarrhea, and dysuria. He was diagnosed with a polyoma virus infection of the bladder by a transurethral bladder biopsy. One year post-transplant, he presented with renal allograft dysfunction and was diagnosed by biopsy with PVN of the non-native kidney. The diagnosis of a polyoma virus infection was confirmed by immunoreactivity to the polyoma T-antigen. We suggest that polyoma virus infection of the bladder be included in the differential diagnosis of urinary dysfunction in post-transplant patients, as such infections might be an under-recognized comorbidity in individuals with PVN.
