B 细胞慢性淋巴细胞白血病的毛细胞转化：一项形态学、细胞化学、表型及分子研究
Hairy cell transformation of a B-cell chronic lymphocytic leukemia: a morphological, cytochemical, phenotypic and molecular study.
作者信息
Duchayne E, Delsol G, Kuhlein E, Klein B, Zhang X G, Attal M, Cassard G, Laurent G
机构信息
Laboratoire de Cytologie et Cytogénétique, CRTS, Purpan, Toulouse, France.
出版信息
Leukemia. 1991 Feb;5(2):150-5.
The normal counterparts of the B cells found in hairy cell leukemia (HCL) are not known. We report here a detailed morphological, cytochemical, immunological and molecular analysis of a patient with B-cell chronic lymphocytic leukemia (B-CLL) who later in the course of his disease developed hairy cell leukemia. We speculate that hairy cell transformation of B-CLL might be related to an in vivo protein kinase C mediated cellular activation of B-CLL cells.
毛细胞白血病（HCL）中发现的B细胞的正常对应细胞尚不清楚。我们在此报告了一名B细胞慢性淋巴细胞白血病（B-CLL）患者的详细形态学、细胞化学、免疫学和分子分析，该患者在疾病进程中后来发展为毛细胞白血病。我们推测B-CLL的毛细胞转化可能与体内蛋白激酶C介导的B-CLL细胞的细胞活化有关。
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