Bramwell Vincent W, Perrie Yvonne
Medicines Research Unit, School of Life and Health Sciences, University of Aston, Birmingham B4 7ET, UK.
J Pharm Pharmacol. 2006 Jun;58(6):717-28. doi: 10.1211/jpp.58.6.0002.
In our attempts to thwart the unwanted attentions of microbes by prophylactic and therapeutic vaccination, the knowledge of interactions at the molecular level may prove to be an invaluable asset. This article examines how particulate delivery systems such as liposomes and polymer microspheres can be applied in the light of recent advances in immunological understanding. Some of the biological interactions of these delivery systems are discussed with relevance for antigen trafficking and molecular pathways of immunogenicity and emphasis on the possible interaction of liposomal components. In particular, traditional concepts such as antigen protection, delivery to antigen presenting cells and depot formation remain important aspects, whilst the inclusion of selected co-adjuvants and enhanced delivery of these moieties in conjunction with antigen now has a firm rationale.
在我们试图通过预防性和治疗性疫苗接种来抵御微生物不必要的侵袭时，分子水平相互作用的知识可能会被证明是一项宝贵的财富。本文根据免疫学认识的最新进展，探讨了脂质体和聚合物微球等颗粒递送系统如何得到应用。讨论了这些递送系统的一些生物学相互作用，涉及抗原转运以及免疫原性的分子途径，并重点关注脂质体成分可能的相互作用。特别是，诸如抗原保护、递送至抗原呈递细胞和储存库形成等传统概念仍然是重要方面，而加入选定的共佐剂以及这些部分与抗原联合的增强递送现在有了坚实的理论基础。
