炎性乳腺癌的分子生物学：在诊断、预后及治疗中的应用

Molecular biology of inflammatory breast cancer: applications to diagnosis, prognosis, and therapy.

作者信息

Wu Mei, Merajver Sofia D

机构信息

Department of Internal Medicine, Division of Hematology and Oncology and Comprehensive Cancer Center, University of Michigan, Ann Arbor, MI 48109-0948, USA.

出版信息

Breast Dis. 2005;22:25-34. doi: 10.3233/bd-2006-22104.

DOI:10.3233/bd-2006-22104

PMID:16735784

Abstract

Inflammatory breast cancer (IBC) presents with unique clinical characteristics (erythema, warming, peau d'orange), rapid progression, and poor survival compared to non-IBC breast cancers. Modern combined modality treatment has significantly improved overall survival. However, IBC treatment remains a major challenge. Recently, rapid progress has been made in the molecular characterization of IBC. In this review, we discuss the current advances in understanding the genetic determinants of IBC with emphasis on their present and potential applications to diagnosis, prognosis, and treatment.

摘要

炎性乳腺癌（IBC）具有独特的临床特征（红斑、发热、橘皮样皮肤），与非炎性乳腺癌相比，进展迅速且生存率低。现代综合治疗方法显著提高了总体生存率。然而，IBC的治疗仍然是一项重大挑战。最近，IBC的分子特征研究取得了快速进展。在本综述中，我们讨论了在理解IBC遗传决定因素方面的当前进展，重点是它们在诊断、预后和治疗中的现状及潜在应用。