Kim Jung Gu, Ku Seung-Yup, Lee Dong Ock, Jee Byung Chul, Suh Chang Suk, Kim Seok Hyun, Choi Young Min, Moon Shin Yong
Department of Obstetrics and Gynecology, College of Medicine, Seoul National University, Seoul, Korea.
Menopause. 2006 May-Jun;13(3):467-73. doi: 10.1097/01.gme.0000182803.06762.fb.
To investigate the relationship of osteocalcin and matrix Gla protein (MGP) gene polymorphisms to serum osteocalcin levels, and bone mineral density (BMD) in postmenopausal Korean women.
The osteocalcin gene Hind III and MGP gene cytosine-adenine polymorphisms were analyzed in 267 postmenopausal Korean women. Serum osteocalcin, bone alkaline phosphatase, C-telopeptide of type I collagen, and BMD at the lumbar spine and femoral neck were measured.
No significant differences in BMD of the lumbar spine and femoral neck were observed across MGP genotypes, whereas a significant lower BMD at the lumbar spine (but not at the femoral neck) was observed in women with the (h) allele (lower case 'h' signifies the presence of the Hind III site) in a dose-response manner. Serum osteocalcin levels among bone turnover markers studied were significantly higher in women without the 210-bp MGP (cytosine-adenine) allele, or with the osteocalcin hh genotype.
The osteocalcin gene Hind III polymorphism is a genetic factor that is associated with BMD of the lumbar spine in Korean women, and Gla gene polymorphisms are associated with higher osteocalcin levels.
研究骨钙素和基质Gla蛋白（MGP）基因多态性与绝经后韩国女性血清骨钙素水平及骨密度（BMD）之间的关系。
对267名绝经后韩国女性的骨钙素基因Hind III和MGP基因胞嘧啶 - 腺嘌呤多态性进行分析。测量血清骨钙素、骨碱性磷酸酶、I型胶原C端肽以及腰椎和股骨颈的骨密度。
不同MGP基因型的女性在腰椎和股骨颈骨密度方面未观察到显著差异，而携带（h）等位基因（小写“h”表示存在Hind III位点）的女性在腰椎（而非股骨颈）骨密度呈剂量反应性显著降低。在研究的骨转换标志物中，无210 bp MGP（胞嘧啶 - 腺嘌呤）等位基因或骨钙素hh基因型的女性血清骨钙素水平显著更高。
骨钙素基因Hind III多态性是与韩国女性腰椎骨密度相关的遗传因素，而Gla基因多态性与较高的骨钙素水平相关。
