Zhou Li, Zhai Lailiang, Yue Bingfang, Lee Edgar D, Lee Milton L
Department of Chemistry and Biochemistry, Brigham Young University, Provo, UT 84602-5700, USA.
Anal Bioanal Chem. 2006 Jul;385(6):1087-91. doi: 10.1007/s00216-006-0523-1. Epub 2006 May 31.
A new interface plate was employed in microspray ionization mass spectrometry (microESI-MS) to improve ion transmission from the sprayer into the sampling nozzle of the mass spectrometer at atmospheric pressure. Using a time-of-flight mass spectrometer (TOFMS), a fivefold increase in ion intensity and a sevenfold reduction in method detection limit were observed. The interface plate attenuated the dependence of the ion intensity on the sprayer position. Even when the distance between the sprayer tip and sampling nozzle was 15.0 mm, ion signals were still stronger than when the sprayer tip was positioned 3.0 mm in front of the sampling nozzle with the original interface plate. This enhancement in the performance of microESI-MS was due to the improved shapes of the equipotential lines near the sprayer tip and the long desolvation distance between the sprayer and the sampling nozzle of the MS.
在微喷雾电离质谱（microESI-MS）中采用了一种新型接口板，以改善在大气压下离子从喷雾器传输到质谱仪采样喷嘴的情况。使用飞行时间质谱仪（TOFMS）时，观察到离子强度增加了五倍，方法检测限降低了七倍。该接口板减弱了离子强度对喷雾器位置的依赖性。即使喷雾器尖端与采样喷嘴之间的距离为15.0毫米，离子信号仍比使用原始接口板时喷雾器尖端位于采样喷嘴前方3.0毫米时更强。microESI-MS性能的这种提高归因于喷雾器尖端附近等势线形状的改善以及喷雾器与质谱仪采样喷嘴之间较长的去溶剂化距离。
