肾脏替代治疗中的收缩和舒张功能：一项横断面研究。

Systolic and diastolic function in renal replacement therapy: a cross-sectional study.

作者信息

Virga Giovambattista, Stomaci Berardino, Munaro Alessandra, Mastrosimone Stefania, Cara Marilena, Artuso Elisabetta, Piovesana Piergiuseppe

机构信息

Nephrology and Dialysis Unit, P. Cosma Hospital, Camposampiero, Padova, Italy.

出版信息

J Nephrol. 2006 Mar-Apr;19(2):155-60.

PMID:16736413

Abstract

BACKGROUND

Heart disease is the main cause of death among uremic patients (pts). Our study aimed to assess left ventricular (LV) systolic and diastolic function in all of our pts on renal replacement therapy (RRT), investigating any differences between hemodialysis (HD), peritoneal dialysis (PD) and transplantation (TX) pts.

METHODS

All pts on RRT at our nephrology unit were enrolled in the study and evaluated once over a period of 6 months: 125 pts were studied: 61 pts on HD, 30 pts on PD and 34 TX pts. Systolic and diastolic function indexes were compared between HD, PD and TX pts. All comparisons were corrected for the effects of age, gender and time on treatment.

RESULTS

HD pts suffered from worse systolic function, with a lower mean fractional shortening and ejection fraction (EF), than TX pts. Twenty percent of HD pts had an EF value <55%. PD pts showed worse diastolic function than TX pts and >80% of them suffered from pathological diastolic indexes. The proportion of hypertensive pts was TX 88.2%, PD 86.7% and HD 50.8%. The percentage of pts with LV hypertrophy (LVH) was TX 55.9%, PD 53.3% and HD 36.1%.

CONCLUSIONS

TX pts had better systolic and diastolic function than HD and PD pts, despite having more hypertension and LVH.

摘要

背景

心脏病是尿毒症患者死亡的主要原因。我们的研究旨在评估所有接受肾脏替代治疗（RRT）的患者的左心室（LV）收缩和舒张功能，调查血液透析（HD）、腹膜透析（PD）和移植（TX）患者之间的差异。

方法

我们肾脏病科所有接受RRT的患者均纳入本研究，并在6个月的时间内进行一次评估：共研究了125例患者：61例接受HD治疗，30例接受PD治疗，34例接受TX治疗。比较HD、PD和TX患者的收缩和舒张功能指标。所有比较均校正了年龄、性别和治疗时间的影响。

结果

HD患者的收缩功能比TX患者差，平均缩短分数和射血分数（EF）较低。20%的HD患者EF值<55%。PD患者的舒张功能比TX患者差，超过80%的患者存在病理性舒张指标。高血压患者的比例分别为：TX 88.2%，PD 86.7%，HD 50.8%。左心室肥厚（LVH）患者的百分比分别为：TX 55.9%，PD 53.3%，HD 36.1%。