Italiano A, Ciais C, Chamorey E, Marcy P Y, Largillier R, Ferrero J M, Thyss A
Centre Regional de Lutte Contre le Cancer Antoine-Lacassagne (Canceropôle PACA), Nice, France.
J Chemother. 2006 Apr;18(2):217-20. doi: 10.1179/joc.2006.18.2.217.
The objective of the study was to determine outcome and satisfaction of cancer patients treated by home-infusions of biphosphonates. 107 patients entered the study and 97 of them chose to receive infusions of zoledronic acid (Z) in the home setting. Patient satisfaction and quality of care (QoC) were assessed by a 22-item questionnaire. Changes from baseline were determined for bone pain using a 0-10 cm visual analogue scale pain score (VAS). Patients expressed a high level of satisfaction specifically with regard to nursing care. Seventy patients experienced a significant decrease in the median pain score during the home-therapy phase not due to an increased use of analgesic therapy (P = 0.03). Z was well tolerated with no major adverse events. The authors conclude that home infusions of biphosphonates, on the condition that the supportive care team is well-organized, is a safe procedure that could be advantageous for patients by increasing satisfaction and compliance with treatment.
本研究的目的是确定接受双膦酸盐居家输注治疗的癌症患者的治疗结果和满意度。107名患者进入研究，其中97名选择在家中接受唑来膦酸（Z）输注。通过一份包含22个条目的问卷评估患者满意度和护理质量（QoC）。使用0至10厘米视觉模拟量表疼痛评分（VAS）确定骨痛相对于基线的变化。患者对护理服务表达了高度满意。70名患者在居家治疗阶段中位疼痛评分显著降低，这并非由于镇痛治疗使用增加所致（P = 0.03）。唑来膦酸耐受性良好，未发生重大不良事件。作者得出结论，在支持性护理团队组织良好的情况下，双膦酸盐居家输注是一种安全的治疗方式，可通过提高患者满意度和治疗依从性而使患者受益。
