Chard M D, Crisp A J
Rheumatology Research Unit, Addenbrooke's Hospital, Cambridge, United Kingdom.
J Rheumatol. 1991 Feb;18(2):203-4.
Mast cells are found in increased numbers in the synovium of patients with rheumatoid arthritis (RA) and may play a role in synovitis. They produce proinflammatory substances including histamine. A double blind placebo controlled study was undertaken in 60 patients with active RA using the H1 receptor blocker, astemizole, as an adjuvant to usual therapies. After 3 months of treatment there were no significant differences in clinical and laboratory variables between the groups. We conclude that H1 antagonist treatment with astemizole has no additional therapeutic effect in RA.
在类风湿关节炎（RA）患者的滑膜中发现肥大细胞数量增加，且肥大细胞可能在滑膜炎中起作用。它们会产生包括组胺在内的促炎物质。一项双盲安慰剂对照研究对60例活动性RA患者进行，使用H1受体阻滞剂阿司咪唑作为常规治疗的辅助药物。治疗3个月后，两组之间的临床和实验室指标无显著差异。我们得出结论，阿司咪唑进行H1拮抗剂治疗对RA没有额外的治疗效果。
