Willesen J L, Jensen A L, Kristensen A T, Kjelgaard-Hansen M, Jessen R, Koch J
Department of Small Animal Clinical Sciences, The Royal Veterinary and Agricultural University, 16 Dyrlaegevej, 1870 Frb. C., Denmark.
J Vet Med A Physiol Pathol Clin Med. 2006 Jun;53(5):266-9. doi: 10.1111/j.1439-0442.2006.00828.x.
Retrospectively, 89 cases of dogs infected with Angiostrongylus vasorum were examined. Fifty-nine of these 89 dogs fulfilled the criteria of not being dually infected with Crenosoma vulpis as well as having a full biochemistry profile including serum fructosamine available. The mean serum fructosamine value of the 59 dogs was 236 micromol/l (reference value 258-348 micromol/l) and significantly lower than the serum fructosamine level of 314 micromol/l in a control group of 42 clinically healthy dogs. Eleven dogs were available for follow up after successful treatment of angiostrongylosis. In this group, the serum fructosamine value rose from a mean of 244 micromol/l to a mean of 320 micromol/l following treatment. Serum glucose, albumin and protein were all within the respective reference ranges at all sampling points. The results indicate that serum fructosamine could be affected by infection with A. vasorum. Furthermore, this change cannot be explained by measurable changes in the level of glucose, albumin or protein. The clinical impact of this study is that a low fructosamine value may indicate infection with A. vasorum thereby suggesting a Baermann test to be performed.
回顾性地检查了89例感染管圆线虫的犬。这89只犬中有59只满足未同时感染狐杯尾线虫且有包括血清果糖胺在内的完整生化指标的标准。这59只犬的血清果糖胺平均值为236微摩尔/升(参考值为258 - 348微摩尔/升),显著低于42只临床健康犬组成的对照组的血清果糖胺水平314微摩尔/升。11只犬在成功治疗血管圆线虫病后可供随访。在该组中,治疗后血清果糖胺值从平均244微摩尔/升升至平均320微摩尔/升。在所有采样点,血清葡萄糖、白蛋白和蛋白质均在各自的参考范围内。结果表明血清果糖胺可能受管圆线虫感染的影响。此外,这种变化无法用葡萄糖、白蛋白或蛋白质水平的可测量变化来解释。本研究的临床意义在于,低果糖胺值可能表明感染了管圆线虫,从而提示应进行贝尔曼试验。