Lukacz Emily S, Lawrence Jean M, Contreras Richard, Nager Charles W, Luber Karl M
Women's Pelvic Medicine Center, University of California, San Diego, La Jolla, California 92037, USA.
Obstet Gynecol. 2006 Jun;107(6):1253-60. doi: 10.1097/01.AOG.0000218096.54169.34.
This study aimed to assess the associations between parity, mode of delivery, and pelvic floor disorders.
The prevalence of pelvic organ prolapse, stress urinary incontinence, overactive bladder, and anal incontinence was assessed in a random sample of women aged 25-84 years by using the validated Epidemiology of Prolapse and Incontinence Questionnaire. Women were categorized as nulliparous, vaginally parous, or only delivered by cesarean. Adjusted odds ratios and 95% confidence intervals (CIs) for each disorder were calculated with logistic regression, controlling for age, body mass index, and parity.
In the 4,458 respondents the prevalence of each disorder was as follows: 7% prolapse, 15% stress urinary incontinence, 13% overactive bladder, 25% anal incontinence, and 37% for any one or more pelvic floor disorders. There were no significant differences in the prevalence of disorders between the cesarean delivery and nulliparous groups. The adjusted odds of each disorder increased with vaginal parity compared with cesarean delivery: prolapse = 1.82 (95% CI 1.04-3.19), stress urinary incontinence = 1.81 (95% CI 1.25-2.61), overactive bladder = 1.53 (95% CI 1.02-2.29), anal incontinence = 1.72 (95% CI 1.27-2.35), and any one or more pelvic floor disorders = 1.85 (95% CI 1.42-2.41). Number-needed-to-treat analysis revealed that 7 women would have to deliver only by cesarean delivery to prevent one woman from having a pelvic floor disorder.
The risk of pelvic floor disorders is independently associated with vaginal delivery but not with parity alone. Cesarean delivery has a protective effect, similar to nulliparity, on the development of pelvic floor disorders when compared with vaginal delivery.
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本研究旨在评估产次、分娩方式与盆底功能障碍之间的关联。
采用经过验证的盆底器官脱垂和尿失禁流行病学调查问卷,对年龄在25 - 84岁的女性随机样本进行盆底器官脱垂、压力性尿失禁、膀胱过度活动症和肛门失禁患病率的评估。女性被分为未生育、经阴道分娩或仅行剖宫产。通过逻辑回归计算每种疾病的调整比值比和95%置信区间(CI),并对年龄、体重指数和产次进行控制。
在4458名受访者中,每种疾病的患病率如下:脱垂7%,压力性尿失禁15%,膀胱过度活动症13%,肛门失禁25%,任何一种或多种盆底功能障碍37%。剖宫产组和未生育组之间疾病患病率无显著差异。与剖宫产相比,经阴道分娩的每种疾病调整后的患病几率均增加:脱垂 = 1.82(95% CI 1.04 - 3.19),压力性尿失禁 = 1.81(95% CI 1.25 - 2.61),膀胱过度活动症 = 1.53(95% CI 1.02 - 2.29),肛门失禁 = 1.72(95% CI 1.27 - 2.35),任何一种或多种盆底功能障碍 = 1.85(95% CI 1.42 - 2.41)。需治疗人数分析显示,7名女性仅通过剖宫产分娩才能预防1名女性出现盆底功能障碍。
盆底功能障碍的风险与阴道分娩独立相关,而非仅与产次相关。与阴道分娩相比,剖宫产对盆底功能障碍的发生具有与未生育相似的保护作用。
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