Ricard-Blum Sylvie, Faye Clément
Institut de Biologie et Chimie des Protéines, UMR 5086 CNRS-UCBL, IFR 128 Biosciences Lyon-Gerland, 7, passage du Vercors, 69367 Lyon Cedex 07.
J Soc Biol. 2005;199(4):321-8. doi: 10.1051/jbio:2005033.
The superfamily of collagens is comprised of 27 members (reviewed by Myllyharju & Kivirikko, 2004; Ricard-Blum & Ruggiero, 2005; Ricard-Blum et al., 2005), which are classified into several subgroups according to their structural features and supramolecular assemblies. Fibrillar collagens and FACITS (Fibril-Associated Collagens with Interrupted Triple helix) are described in the paper by Ruggiero et al. in this issue. Our paper reports recent advances on collagens associated to basement membranes. It focuses on the multiplexin family (including collagens XV and XVIII) and on membrane collagens present in skin, namely collagens XIII and XVII. The mechanisms leading to the shedding of their ectodomain from cell membrane and the biological roles of their shedded domains are discussed. The last part of the paper is devoted to several fragments of basement membrane collagens, called matricryptins or matrikins, and to their biological activities.
胶原蛋白超家族由27个成员组成（Myllyharju和Kivirikko于2004年、Ricard-Blum和Ruggiero于2005年、Ricard-Blum等人于2005年进行了综述），根据其结构特征和超分子组装可分为几个亚组。Ruggiero等人在本期发表的论文中描述了纤维状胶原蛋白和FACITS（具有中断三螺旋的纤维相关胶原蛋白）。我们的论文报道了与基底膜相关的胶原蛋白的最新进展。它聚焦于多重蛋白聚糖家族（包括胶原蛋白XV和XVIII）以及皮肤中存在的膜胶原蛋白，即胶原蛋白XIII和XVII。文中讨论了导致它们的胞外域从细胞膜脱落的机制以及脱落结构域的生物学作用。论文的最后一部分致力于基底膜胶原蛋白的几个片段，称为基质隐窝蛋白或基质信号肽，以及它们的生物学活性。
