糖尿病及饮食调控对大鼠腮腺对交感神经刺激分泌反应的影响。

Effects of diabetes and dietary manipulation on rat parotid gland secretory response to sympathetic nerve stimulation.

Anderson L C

Department of Oral Biology, University of Washington, School of Dentistry, Seattle 98195.

Comp Biochem Physiol A Comp Physiol. 1991;98(2):363-6. doi: 10.1016/0300-9629(91)90548-q.

Abstract

The effects of streptozotocin-diabetes, bulk-diet, low protein diet (8%) and protein-calorie malnutrition on parotid gland response to sympathetic nerve stimulation were studied in male Wistar rats. 2. Mean body weights were considerably less in diabetic and protein-calorie malnourished rats than in the other groups, but parotid gland weight was reduced only in animals placed on a low-protein diet. 3. Salivary flow rate (microliter/min/g tissue) and total protein output (mg secreted/g tissue) were reduced in diabetic rats. 4. Salivary composition was altered in diabetes and protein-calorie restriction, and the specific changes were unique to each condition. 5. Thus, with the possible exception of gland weight the effects of diabetes on parotid gland structure and function are not related to either hyperphagia or nutritional status.

摘要

在雄性Wistar大鼠中研究了链脲佐菌素诱导的糖尿病、大量饮食、低蛋白饮食（8%）以及蛋白质-热量营养不良对腮腺对交感神经刺激反应的影响。2. 糖尿病和蛋白质-热量营养不良大鼠的平均体重显著低于其他组，但只有低蛋白饮食组动物的腮腺重量减轻。3. 糖尿病大鼠的唾液流速（微升/分钟/克组织）和总蛋白分泌量（毫克/分泌/克组织）降低。4. 糖尿病和蛋白质-热量限制会改变唾液成分，且每种情况的具体变化都是独特的。5. 因此，除了腺体重量外，糖尿病对腮腺结构和功能的影响与食欲亢进或营养状况均无关。