Buzogány István, Bagheri Fariborz, Süle Norbert, Magyarlaki Tamás, Kalmár-Nagy Károly, Farkas László, Pajor Gábor
Department of Urology, Medical School, University of Pécs, Germany.
Anticancer Res. 2006 Jan-Feb;26(1B):751-3.
Renal carcinosarcoma is a rare tumor with 12 reported cases in the world literature. To our knowledge, carcinosarcoma of a renal allograft has not been reported to date.
A multifocal urothelial carcinosarcoma of a transplanted kidney in a 49-year-old woman is described. Genomic analysis of the extracted nuclei of all the neoplastic cells showed uniformly XY genotype proving the transplant origin of the tumor.
The carcinogenic role of immunosuppressive medications in kidney-transplanted patients is reported in the literature. In this case, immunosuppression may have promoted the carcinosarcoma.
Renal transplant patients should be monitored for the development of malignancy in the allograft and elsewhere.
肾癌肉瘤是一种罕见肿瘤，世界文献中报道了12例。据我们所知，迄今为止尚未报道过同种异体肾移植的癌肉瘤。
描述了一名49岁女性移植肾的多灶性尿路上皮癌肉瘤。对所有肿瘤细胞提取的细胞核进行基因组分析，结果显示均为XY基因型，证实了肿瘤的移植来源。
文献报道了免疫抑制药物在肾移植患者中的致癌作用。在本病例中，免疫抑制可能促进了癌肉瘤的发生。
肾移植患者应监测同种异体肾及其他部位是否发生恶性肿瘤。
