Dorn M
Casore del Monte (PT), Italien.
MMW Fortschr Med. 2004 Aug 5;146 Suppl 2:57-60.
To identify the efficacy and tolerance of activated charcoal in acute, nonspecific diarrhea.
Randomized, double-blind study on 100 adults with nonspecific diarrhea, performed in two general practices. 94 were included in the final analysis, 6 patients - all from the placebo group abandoned treatment because of the absence of an effect.
The major outcome parameters - reduction of stool frequency and curtailment of the duration of the diarrhea - were unequivocally achieved. Differences between the agent and placebo were great. Stool frequency decreased significantly from the third day in the drug group, and highly significantly from the fourth day. The superiority of the antidiarrheal was also clearly evident in terms of the numbers of days with diarrhea, the clinical findings tympania, nature of the stool and of eight individual symptoms, the summed score of which was improved highly significantly by the test substance.
The substance tested proved rapidly and reliably effective in the treatment of nonspecific diarrhea, and was well tolerated. Activated charcoal, together with oral rehydration, can therefore be recommended as an initial measure for treating diarrhea with the aim of rapidly and effectively preventing loss of fluid and electrolytes and relieving symptoms.
确定活性炭对急性非特异性腹泻的疗效及耐受性。
在两家普通诊所对100名患有非特异性腹泻的成年人进行随机双盲研究。最终分析纳入94人，6名患者——均来自安慰剂组——因无效而放弃治疗。
主要结局参数——排便次数减少和腹泻持续时间缩短——均明确达成。该药物与安慰剂之间差异显著。药物组从第三天起排便次数显著减少，从第四天起极显著减少。在腹泻天数、临床体征鼓音、粪便性质以及八项个体症状方面，止泻药的优势也明显可见，测试物质使其总分极显著改善。
经测试的该物质在治疗非特异性腹泻方面迅速且可靠地发挥了作用，并且耐受性良好。因此，活性炭与口服补液一起，可作为治疗腹泻的初始措施推荐，旨在快速有效地防止体液和电解质流失并缓解症状。
